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Common Treatment for Meth O.D. May Cause Brain Damage

A new study from researchers at the Boston University School of Medicine reveals that a common anti-psychotic drug used in emergency rooms to treat Meth overdoses in patients damages brain cells in an area known to regulate movement. 

The experiments indicate that the damage is only caused when a person with Meth in his system is treated with the medication haloperidol.  Neither Meth nor haloperidol alone leads to the destructive effects.  Research shows the damage may predispose some people who have been treated for a Meth overdose to seizures and the development of movement disorders, although the study did not measure movement specifically.  The scientists hope to conduct further research to find out if the loss of cells results in abnormal involuntary movements resembling Tourette's syndrome and Huntington's disease.

Haloperidol Treatment after High-Dose Methamphetamine Administration Is Excitotoxic to GABA Cells in the Substantia Nigra Pars Reticulata

Theo Hatzipetros, Jamie G. Raudensky, Jean-Jacques Soghomonian, and Bryan K. Yamamoto J.
Published in The Journal of Neuroscience, May 30, 2007, 27(22):5895-5902; doi:10.1523/JNEUROSCI.5260-06.2007


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